Noritake M, Takase B, Kudoh K, Kugai N, Kurita A, Nagata N
Third Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
Intern Med. 1992 Apr;31(4):453-6. doi: 10.2169/internalmedicine.31.453.
We assessed the hourly coefficient of variance of RR intervals (CVRR) in 29 subjects with non-insulin-dependent diabetes mellitus and 19 age-matched healthy subjects using an ambulatory 24-hour ECG monitoring system. We also evaluated CVRR during 100 beats in both groups in the supine posture at 07:00 and 10:00 in the morning. Hourly CVRR showed an overt diurnal variation in both groups especially in the daytime and at midnight, but was significantly lower (p less than 0.05) in diabetic patients. CVRR during resting 100 beats at 07:00 was significantly higher (p less than 0.05) than that at 10:00 in both groups. These findings indicate that HRV shows an obvious diurnal variation in both groups. As a steep and marked change occurs in the morning, careful consideration is necessary to assess the test performed for a short time span at random times throughout the day, particularly in the morning.
我们使用动态24小时心电图监测系统，评估了29名非胰岛素依赖型糖尿病患者和19名年龄匹配的健康受试者RR间期的每小时变异系数（CVRR）。我们还在上午7点和10点对两组受试者仰卧位时的100次心跳期间的CVRR进行了评估。每小时CVRR在两组中均呈现明显的昼夜变化，尤其是在白天和午夜，但糖尿病患者的CVRR显著更低（p小于0.05）。两组在上午7点静息100次心跳期间的CVRR均显著高于上午10点时（p小于0.05）。这些发现表明，两组的心率变异性均呈现明显的昼夜变化。由于早晨会出现急剧且显著的变化，因此在评估全天随机时间段内短时间进行的测试时，尤其是在早晨，需要谨慎考虑。
