Kanemoto N, Aoki N, Goto Y
Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Intern Med. 1992 Apr;31(4):486-8. doi: 10.2169/internalmedicine.31.486.
A patient with myelocytic leukemia who showed electrical alternans of the T-U wave with no change in the QRS complex following chemotherapy is described. Electrocardiogram taken 4 days later showed ventricular quadrigeminy in which the T-U wave of the first sinus beat after the ventricular premature contraction was markedly less prominent compared to the successive two sinus beats which showed marked prolongation and inverted T-U waves. The causative factors for alternans of T-U waves may include hypochloremic alkalosis with hypopotassemia and myocardial damage by anticancer drugs such as daunomycin and aclarubicin chloride used for the underlying disease.
本文描述了一名髓细胞白血病患者，化疗后出现T-U波电交替，QRS波群无变化。4天后的心电图显示室性四联律，室性早搏后的第一个窦性搏动的T-U波明显不如随后两个窦性搏动突出，后两个窦性搏动的T-U波明显延长且倒置。T-U波交替的病因可能包括低氯性碱中毒伴低钾血症以及用于基础疾病的抗癌药物（如柔红霉素和盐酸阿克拉霉素）所致的心肌损伤。
