一家养老院爆发军团菌肺炎。

An outbreak of Legionnaires' pneumonia in a nursing home.

作者信息

Maesaki S, Kohno S, Koga H, Kaku M, Yoshitomi Y, Yamada H, Matsuda H, Higashiyama Y, Hara K, Seto M

机构信息

Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.

出版信息

Intern Med. 1992 Apr;31(4):508-12. doi: 10.2169/internalmedicine.31.508.

DOI:10.2169/internalmedicine.31.508

PMID:1633359

Abstract

An outbreak of Legionnaires' pneumonia occurred at a nursing home in December 1990. A 79-year-old female and a 73-year-old male clerk who were staying at the nursing home developed pneumonia with only a 5-day interval. Legionella pneumophila serogroup I was isolated from transtracheal aspirate of the former and sputum of the latter. After treatment with a combination of erythromycin and rifampicin both patients improved. Serological surveillance of inpatients and staff of the nursing home was performed in February 1991. Seven out of 51 samples (14.0%) showed a titer higher than 1:128 of anti-Legionella pneumophila serogroup I antibody determined by indirect immunofluorescence; two of these seven complained of respiratory symptoms. Molecular epidemiology analyzed by restriction endonuclease digestion of isolated L. pneumophila showed an identical pattern which suggested a common origin.

摘要

1990年12月，一家养老院爆发了军团病肺炎。住在该养老院的一名79岁女性和一名73岁男性职员在仅间隔5天的时间里相继患上肺炎。从前一位患者的经气管吸出物和后一位患者的痰液中分离出嗜肺军团菌血清1型。经红霉素和利福平联合治疗后，两名患者均有所好转。1991年2月对该养老院的住院患者和工作人员进行了血清学监测。在51份样本中，有7份（14.0%）通过间接免疫荧光法测定的抗嗜肺军团菌血清1型抗体滴度高于1:128；这7人中有两人诉说有呼吸道症状。通过对分离出的嗜肺军团菌进行限制性内切酶消化分析的分子流行病学显示出相同的模式，这表明有共同的来源。