Karita Kanae, Nakao Mutsuhiro, Nishikitani Mariko, Nomura Kyoko, Yano Eiji
Department of Hygiene and Public Health, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8605, Tokyo, Japan.
Int Arch Occup Environ Health. 2006 May;79(5):441-4. doi: 10.1007/s00420-005-0062-7. Epub 2005 Dec 7.
The objective of the study was to clarify the relationship between major subjective symptoms and autonomic nervous system function by power spectral analysis of heart rate variability (HRV).
Short-term HRV was examined for 413 male workers in a Japanese information service company aged 19-45 years, and questionnaire survey on subjective symptoms and biochemical measurements were conducted at annual health checkup.
The most prevalent subjective symptom (> or =10%) was dullness, followed by fatigue, backache, diarrhea, sleep disorder, and irritation. HRV in high frequency (HF 0.15-0.40 Hz) bands and the coefficient of variance in the electrocardiographic R-R interval (CVrr) were lower in the subjects with any of these six symptoms than in those without the symptoms. Both parameters were negatively associated with the reporting of any of the six symptoms by multiple regression analyses, controlling for the significant effects of age (HF and CVrr) and plasma cortisol levels (HF).
It was suggested that the reporting of the subjective symptoms is one of good predictors for reduced parasympathetic tones.
本研究的目的是通过心率变异性（HRV）的功率谱分析来阐明主要主观症状与自主神经系统功能之间的关系。
对一家日本信息服务公司的413名年龄在19至45岁之间的男性员工进行了短期HRV检测，并在年度健康检查时进行了主观症状问卷调查和生化指标检测。
最常见的主观症状（≥10%）是迟钝，其次是疲劳、背痛、腹泻、睡眠障碍和易怒。出现这六种症状中任何一种的受试者，其高频（HF 0.15 - 0.40 Hz）频段的HRV以及心电图R-R间期的变异系数（CVrr）均低于无这些症状的受试者。通过多元回归分析，在控制年龄（HF和CVrr）和血浆皮质醇水平（HF）的显著影响后，这两个参数与六种症状中任何一种症状的报告均呈负相关。
提示主观症状的报告是副交感神经张力降低的良好预测指标之一。
