Voytko M L, Kitt C A, Price D L
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Cereb Cortex. 1992 Jan-Feb;2(1):48-55. doi: 10.1093/cercor/2.1.48.
Cholinergic processes in anterior temporal cortex of rhesus monkeys were identified using immunocytochemical techniques for ChAT. Labeled fibers were present throughout the temporal pole and anterior aspects of the superior temporal, middle temporal, and inferior temporal gyri. ChAT-immunoreactive fibers were most dense in layer I to superficial layer III throughout anterior temporal cortex. In temporal pole, agranular and dysgranular regions had a greater density of labeled fibers in superficial layers as compared to granular regions. In addition to the superficial concentration of cholinergic fibers in lateral temporal regions, numerous labeled fibers were also present in deep cortical layers in the inferior temporal gyrus of lateral temporal cortex, with lesser concentrations of immunoreactive fibers present in these layers in superior and middle temporal gyri. These patterns of cholinergic innervation may reflect the degree of cholinergic modulation of functions in anterior temporal cortex.
利用针对胆碱乙酰转移酶（ChAT）的免疫细胞化学技术，鉴定了恒河猴颞叶前部皮质中的胆碱能过程。标记纤维存在于整个颞极以及颞上回、颞中回和颞下回的前部。在整个颞叶前部皮质中，ChAT免疫反应性纤维在I层至浅III层最为密集。在颞极，与颗粒区相比，无颗粒区和颗粒减少区在浅层有更高密度的标记纤维。除了颞叶外侧区域胆碱能纤维在浅层的集中分布外，颞叶外侧皮质颞下回的深层皮质层中也存在大量标记纤维，而在颞上回和颞中回的这些层中，免疫反应性纤维的浓度较低。这些胆碱能神经支配模式可能反映了颞叶前部皮质中功能的胆碱能调节程度。
