Bhaskar A S B, Jayaraj R, Dangi R S, Prasad G K, Singh Beer, Rao P V Lakshmana
Division of Pharmacology and Toxicology, Defence R& D Establishment, Gwalior, India.
J Environ Biol. 2005 Jul;26(3):511-5.
Most frequently encountered freshwater cyanobacterial toxin is Microcystin-LR (MC-LR). Microcystins released from cells into water have been responsible for the death of humans, domestic and wild animals. Removal of microcystin by active carbon has been one of the best methods available so far. This study evaluates three grades of active carbon namely 40, 60 and 80 CTC for their removal efficiency of MC-LR from contaminated water. Kinetics of toxin removal was studied in time course experiments. Protection in mouse model was studied for the samples after the adsorption. Toxin quantitation was done by HPLC method. The MC-LR concentration after 24 hr treatment with 40, 60 and 80 CTC carbons were 4.8, 3.3 and 1.3 microg/ml respectively from an initial concentration of 5.2 microg/ml. Protection in mouse bioassay was seen after 48, 24 and 2 hr of adsorption time respectively for 40, 60 and 80 CTC carbons. 80 CTC carbon was found to be most efficient in removing MC-LR from contaminated water.
最常遇到的淡水蓝藻毒素是微囊藻毒素-LR（MC-LR）。从细胞释放到水中的微囊藻毒素已导致人类、家畜和野生动物死亡。用活性炭去除微囊藻毒素是目前可用的最佳方法之一。本研究评估了三种等级的活性炭，即40、60和80 CTC，考察它们从受污染水中去除MC-LR的效率。在时间进程实验中研究了毒素去除动力学。对吸附后的样品进行了小鼠模型保护研究。通过高效液相色谱法进行毒素定量。用40、60和80 CTC活性炭处理24小时后，MC-LR浓度分别从初始浓度5.2微克/毫升降至4.8、3.3和1.3微克/毫升。40、60和80 CTC活性炭吸附时间分别为48、24和2小时后，在小鼠生物测定中观察到有保护作用。发现80 CTC活性炭从受污染水中去除MC-LR的效率最高。
