Saisho Toshimitsu, Okusaka Takuji, Ueno Hideki, Morizane Chigusa, Okada Shuichi
Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
Hepatogastroenterology. 2005 Nov-Dec;52(66):1654-8.
BACKGROUND/AIMS: Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy have not been fully examined. This study investigated prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy.
Sixty-five consecutive chemo-naive patients with advanced biliary tract cancer, who received chemotherapy, were analyzed retrospectively to investigate prognostic factors.
Median survival time and overall survival rates at 1 and 2 years were 180 days, 21%, and 5%, respectively. By multivariate analysis using the Cox proportional hazards model, performance status of 0, 1, serum C-reactive protein level of < or = 1.0mg/dL, serum albumin level of > or = 3.5g/dL, serum lactate dehydrogenase level of < or = 500 U/L, and being female were independent favorable prognostic factors. A prognostic index based on the coefficients of these prognostic factors was used to classify patients into three groups with good, intermediate, and poor prognoses. The median survival times for these three groups were 246, 152, and 33 days, respectively.
The results may be helpful for predicting life expectancy, determining treatment strategies, and designing future clinical trials in patients with advanced biliary tract cancer.
背景/目的：晚期胆管癌患者接受化疗的预后因素尚未得到充分研究。本研究调查了晚期胆管癌患者接受化疗的预后因素。
对65例连续的晚期胆管癌初治患者进行回顾性分析，这些患者均接受了化疗以研究预后因素。
中位生存时间以及1年和2年的总生存率分别为180天、21%和5%。通过使用Cox比例风险模型进行多因素分析，体能状态为0、1，血清C反应蛋白水平≤1.0mg/dL，血清白蛋白水平≥3.5g/dL，血清乳酸脱氢酶水平≤500U/L以及女性是独立的有利预后因素。基于这些预后因素系数的预后指数用于将患者分为预后良好、中等和不良的三组。这三组的中位生存时间分别为246天、152天和33天。
这些结果可能有助于预测晚期胆管癌患者的预期寿命、确定治疗策略以及设计未来的临床试验。
