Jiao Long R, Navarra Guiseppe, Weber Jean-Christophe, Havlik Roman, Nicholls Joanna P, Habib Nagy A
Department of Surgical Oncology and Technology, Faculty of Medicine, Imperial College of Science Technology & Medicine, London, UK.
Hepatogastroenterology. 2005 Nov-Dec;52(66):1685-7.
Surgical resection remains the curative procedure for liver tumors, but even with improvements in method it is still a major operation with significant morbidity and mortality in experts' hands, and a long learning curve for those surgeons who undertake it. Recently radiofrequency ablation has gained some credibility as an alternative method of dealing with liver tumors deemed unresectable. A novel technique of liver resection assisted by the application of radiofrequency is described here. A patient with colorectal liver metastases underwent a segment II/III liver resection with this technique. Following laparotomy, the tumor was identified with intraoperative ultrasound and a 'cooled-tipped' radiofrequency probe was used to ablate liver parenchyma 2cm away from the edge of the tumor. To achieve full thickness of radiofrequency ablation, several insertions were applied. The effect of radiofrequency on liver parenchyma was monitored with an intraoperative ultrasound by micro-bubbles generated by radiofrequency ablation. The length of the resection was 45 min with a blood loss of 30mL. The patient was discharged on the 6th postoperative day without complications. In this report we indicate how the use of radiofrequency ablation can be combined with standard surgical resection of liver cancers to provide a quick, and relatively bloodless operation that is likely to reduce morbidity and mortality and is easy for its practitioners to learn.
手术切除仍然是治疗肝脏肿瘤的根治性方法,但即便手术方法有所改进,在专家手中它仍是一项大手术,具有较高的发病率和死亡率,对于实施该手术的外科医生而言学习曲线漫长。近来,射频消融作为处理不可切除肝脏肿瘤的一种替代方法已获得一定认可。本文描述了一种应用射频辅助肝脏切除的新技术。一名患有结直肠癌肝转移的患者采用该技术进行了肝Ⅱ/Ⅲ段切除。剖腹术后,通过术中超声识别肿瘤,使用“冷循环”射频探头对距肿瘤边缘2厘米处的肝实质进行消融。为实现射频消融的全层效果,进行了多次插入操作。通过术中超声利用射频消融产生的微泡监测射频对肝实质的影响。切除时长45分钟,失血30毫升。患者术后第6天出院,无并发症。在本报告中,我们指出如何将射频消融与标准肝癌手术切除相结合,以提供一种快速、相对无血的手术,这可能会降低发病率和死亡率,且便于从业者学习。