Kanematsu Takashi, Furui Junichiro, Yanaga Katsuhiko, Okudaira Sadayuki, Kamohara Yukio, Eguchi Susumu
Department of Surgery II, Nagasaki University School of Medicine, Japan.
Hepatogastroenterology. 2005 Nov-Dec;52(66):1828-31.
BACKGROUND/AIMS: In the present study the importance of measurement of portal venous pressure was focused on to predict the postoperative liver function before liver surgery, particularly in cirrhotic patients.
Ninety-two patients who underwent a hepatic resection for hepatocellular carcinoma (HCC) were retrospectively evaluated to predict their postoperative liver function by measuring the portal venous pressure.
The portal venous pressure was not significantly correlated with the preoperative value of the indocyanine green (ICG) retention test. In patients with an ICG of over 20%, the risk of occurrence of postoperative hyperbilirubinemia was high when a major hepatic resection was the procedure of choice. Even in patients with an ICG of below 20%, a few patients developed complications after surgery when major resection was carried out. For patients undergoing a small excision, the complications were nil when the ICG was below 20% and the pressure was below 200mm in saline.
The portal venous pressure was found to reflect to what degree the liver parenchyma is damaged. Measuring the portal venous pressure is useful for determining the final indications for surgery also in cirrhotic patients with HCC.
背景/目的:在本研究中,重点关注门静脉压力测量对于预测肝脏手术尤其是肝硬化患者术后肝功能的重要性。
对92例行肝细胞癌(HCC)肝切除术的患者进行回顾性评估,通过测量门静脉压力来预测其术后肝功能。
门静脉压力与术前吲哚菁绿(ICG)滞留试验值无显著相关性。ICG超过20%的患者,若选择进行大范围肝切除,术后发生高胆红素血症的风险较高。即使ICG低于20%的患者,进行大范围切除术后仍有少数患者出现并发症。对于接受小范围切除的患者,当ICG低于20%且盐水柱压力低于200mm时,无并发症发生。
发现门静脉压力可反映肝实质受损的程度。测量门静脉压力对于确定HCC肝硬化患者的最终手术指征也很有用。