Van Westen D, Skagerberg G, Olsrud J, Fransson P, Larsson E M
Department of Diagnostic Radiology and Department of Neurosurgery, University Hospital, Lund, Sweden.
Acta Radiol. 2005 Oct;46(6):599-609. doi: 10.1080/02841850510021652.
To investigate the potential of functional magnetic resonance imaging (fMRI) at 3T as a clinical tool in the preoperative evaluation of patients with intracranial tumors. High magnetic field strength such as 3T is of benefit for fMRI because signal-to-noise ratio and sensitivity to susceptibility changes are field-strength-dependent.
Twenty patients with tumors close to eloquent sensorimotor or language areas were studied. Motor, sensory, and two language paradigms (word generation, rhyming) were used; their effectiveness was determined as the percentage of patients in whom the functional area of interest was activated. Activation maps were calculated and their quality rated as high, adequate, or insufficient. The influence of fMRI on the neurosurgical decision regarding operability, surgical approach, and extent of the resection, was assessed.
Paradigm effectiveness was 90% for motor and 95% for sensory stimulation, and varied from 79% to 95% for word generation and rhyming in combination. Ninety percent of the activation maps held high or adequate quality. fMRI proved useful: in the decision to operate (9 patients), in the surgical approach (13 patients), and in extent of the resection (12 patients).
fMRI at 3T is a clinically applicable tool in the work-up of patients with intracranial tumors.
研究3T功能磁共振成像（fMRI）作为颅内肿瘤患者术前评估临床工具的潜力。诸如3T这样的高磁场强度对fMRI有益，因为信噪比和对磁化率变化的敏感性取决于场强。
对20例肿瘤靠近明确的感觉运动区或语言区的患者进行研究。使用运动、感觉以及两种语言范式（单词生成、押韵）；通过感兴趣功能区被激活的患者百分比来确定其有效性。计算激活图并将其质量评定为高、适当或不足。评估fMRI对神经外科手术关于可操作性、手术入路和切除范围决策的影响。
运动刺激的范式有效性为90%，感觉刺激为95%，单词生成和押韵组合的有效性在79%至95%之间变化。90%的激活图质量高或适当。fMRI被证明是有用的：在手术决策方面（9例患者）、手术入路方面（13例患者）以及切除范围方面（12例患者）。
3T的fMRI是颅内肿瘤患者检查中的一种临床适用工具。
