大脑胶质瘤病的多体素磁共振波谱分析

Multivoxel magnetic resonance spectroscopy in gliomatosis cerebri.

作者信息

Uysal E, Erturk M, Yildirim H, Karatag O, Can M, Tanik C, Basak M

机构信息

Department of Radiology, Department of Neurosurgery and Department of Pathology, Sisli Etfal Hospital, Istanbul, Turkey.

出版信息

Acta Radiol. 2005 Oct;46(6):621-4. doi: 10.1080/02841850510021751.

DOI:10.1080/02841850510021751

PMID:16334845

Abstract

Gliomatosis cerebri is a rare entity with non-specific clinical and conventional magnetic resonance imaging (MRI) findings; accurate diagnosis is a differential diagnostic challenge. MR spectroscopy has recently been introduced as a useful diagnostic tool for detection of this entity. We present a gliomatosis cerebri case in which we made the radiological diagnosis using the MR spectroscopy findings; the diagnosis was confirmed by subsequent biopsy and histopathologic evaluation. Multivoxel spectroscopy (CSI, PRESS, 1500/135) shows a marked increase in Cho/NAA (6.6), normal to mild increase in Cho/Cr (1.2), and marked decrease in NAA/Cr (0.2) compared with the normally appearing contralateral side (Cho/NAA: 0.8, Cho/Cr: 0.9, NAA/Cr: 1.2).

摘要

大脑胶质瘤病是一种罕见的疾病，具有非特异性的临床和传统磁共振成像（MRI）表现；准确诊断是一项鉴别诊断挑战。磁共振波谱最近已被引入作为检测该疾病的一种有用诊断工具。我们报告一例大脑胶质瘤病病例，我们利用磁共振波谱结果做出了影像学诊断；随后的活检和组织病理学评估证实了该诊断。与对侧正常表现相比，多体素波谱（CSI，PRESS，1500/135）显示胆碱/ N - 乙酰天门冬氨酸（Cho/NAA）显著升高（6.6），胆碱/肌酸（Cho/Cr）正常至轻度升高（1.2），N - 乙酰天门冬氨酸/肌酸（NAA/Cr）显著降低（0.2）（对侧Cho/NAA：0.8，Cho/Cr：0.9，NAA/Cr：1.2）。