人类巨细胞病毒刺激宿主细胞的RNA合成。
Human cytomegalovirus stimulates host cell RNA synthesis.
作者信息
Tanaka S, Furukawa T, Plotkin S A
出版信息
J Virol. 1975 Feb;15(2):297-304. doi: 10.1128/JVI.15.2.297-304.1975.
Abstract
Human cytomegalovirus infection of human fibroblast cells (WI-38) induced cellular RNA synthesis. The RNA synthesis in infected cultures preceded the synthesis of viral DNA and progeny virus by approximately 24 h. RNA species synthesized in infected cells included ribosomal 28S and 18S; and 4S transfer RNA; all were markedly increased in comparison to uninfected cells. This induction of host cell RNA synthesis was dependent upon a protein(s) that was synthesized during the early stages of infection.
摘要
人巨细胞病毒对人成纤维细胞（WI - 38）的感染诱导了细胞RNA合成。受感染培养物中的RNA合成比病毒DNA和子代病毒的合成提前约24小时。在受感染细胞中合成的RNA种类包括核糖体28S和18S；以及4S转移RNA；与未感染细胞相比，所有这些RNA的合成均显著增加。宿主细胞RNA合成的这种诱导依赖于感染早期合成的一种蛋白质。
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