Mandato Vincenzo Dario, Sammartino Annalidia, Di Carlo Costantino, Tommaselli Giovanni A, Tauchmanovà Libuse, D'Elia Antonio, Nappi Carmine
Department of Obstetrics and Gynecology, University of Naples Federico II, Naples, Italy.
Gynecol Endocrinol. 2005 Sep;21(3):149-53. doi: 10.1080/09513590500196168.
The objective of our study was to evaluate bone density in Italian postmenopausal women without clinical risk factors for osteoporosis resident in the Naples area using quantitative ultrasonometry of bone (QUS). Subjects were 1149 Italian postmenopausal women (age: 54.9 +/- 5.0 years (mean +/- standard deviation); range: 45-74 years) resident in the Naples area. Clinical risk factors for osteoporosis resulting in exclusion from the study were family history of osteoporosis, dietary, smoking and alcohol habits, personal history of fractures and/or metabolic diseases. The following QUS parameters were calculated: amplitude-dependent speed of sound (AD-SoS), T-score and Z-score. We found significant inverse correlations between AD-SoS and age (r = - 0.23), time since menopause (r = - 0.25) and body mass index (BMI) (r = - 0.16). The same was observed for T-score. In contrast, Z-score showed a significant positive correlation with age and time since menopause, and a negative correlation with BMI. A T-score suggestive of high risk for osteoporosis (less than -3.2) was found in 1.6% of subjects, while a T-score suggestive of moderate risk for osteoporosis (between -3.2 and -2) was found in 19.3% of patients. In this group of women without clinical risk factors for osteoporosis we found a very low prevalence of QUS results suggesting a high risk for osteoporosis. However, a condition of 'moderate' risk for osteoporosis was present in a remarkable percentage of these women.
我们研究的目的是通过骨定量超声检查（QUS）评估那不勒斯地区无骨质疏松临床风险因素的意大利绝经后女性的骨密度。研究对象为1149名居住在那不勒斯地区的意大利绝经后女性（年龄：54.9±5.0岁（均值±标准差）；范围：45 - 74岁）。导致被排除在研究之外的骨质疏松临床风险因素包括骨质疏松家族史、饮食、吸烟和饮酒习惯、骨折和/或代谢疾病个人史。计算了以下QUS参数：振幅依赖声速（AD - SoS）、T值和Z值。我们发现AD - SoS与年龄（r = - 0.23）、绝经后时间（r = - 0.25）和体重指数（BMI）（r = - 0.16）之间存在显著负相关。T值也观察到同样情况。相比之下，Z值与年龄和绝经后时间呈显著正相关，与BMI呈负相关。1.6%的受试者T值提示骨质疏松高风险（小于 - 3.2），而19.3%的患者T值提示骨质疏松中度风险（- 3.2至 - 2之间）。在这组无骨质疏松临床风险因素的女性中，我们发现提示骨质疏松高风险的QUS结果患病率非常低。然而，这些女性中有相当比例存在“中度”骨质疏松风险状况。
