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外用皮质类固醇校准扩张术治疗尿道下裂修复术后新尿道口狭窄

Calibration and dilatation with topical corticosteroid in the treatment of stenosis of neourethral meatus after hypospadias repair.

作者信息

Radojicic Zoan I, Perovic Sava V, Stojanoski Krste D J

机构信息

Paediatric Urology, University Children's Hospital, Belgrade, Serbia, Yugoslavia.

出版信息

BJU Int. 2006 Jan;97(1):166-8. doi: 10.1111/j.1464-410X.2006.05870.x.

Abstract

OBJECTIVE

To assess the early disclosure and treatment of meatal stenosis after hypospadias repair, using calibration of the neourethral meatus at regular intervals to detect stenosis, and to assess the curative effects of dilatation with topical corticosteroids.

PATIENTS AND METHODS

Between 2001 and 2003, 83 boys (median age 19 months, range 12-28) had a proximal hypospadias repair using a tubularized skin island-flap urethroplasty. The neourethra was calibrated every 7-15 days with newly designed small and fine metal sounds (5-12 F) for 3 months starting 7-10 days after surgery. The patients with meatal stenosis were treated by dilatation using topical 0.05% betamethasone cream daily (twice per day) for 3 months.

RESULTS

The mean (range) follow-up was 29 (12-37) months; 19 patients who developed early stenosis were treated by dilatation with topical steroids. After treatment, 14 neourethras were passable with a minimum sound of 10 F at regular 6-12 months assessments. Stenosis persisted in five patients who did not respond to the treatment; of these, a diverticulum developed in one and a fistula in two. All patients with permanent complications were re-operated. There were no adverse effects in any of the patients treated with topical 0.05% betamethasone cream.

CONCLUSION

Early calibration and dilatation of the neourethra after hypospadias repair is a useful method for the early disclosure and treatment of meatal stenosis. The newly designed sounds made calibration/dilatation less unpleasant and more acceptable for the patient. Topical corticosteroids improved scar elasticity, which facilitated dilatation and prevented the formation of meatal stenosis.

摘要

目的

评估尿道下裂修复术后尿道口狭窄的早期发现与治疗情况,通过定期对新尿道尿道口进行校准以检测狭窄,并评估局部使用皮质类固醇进行扩张的疗效。

患者与方法

2001年至2003年期间,83名男孩(中位年龄19个月,范围12 - 28个月)接受了近端尿道下裂修复术,采用管状带蒂皮瓣尿道成形术。术后7 - 10天开始,每7 - 15天用新设计的细小金属探子(5 - 12F)对新尿道进行校准,持续3个月。尿道口狭窄的患者每天(每天两次)使用0.05%倍他米松乳膏进行局部扩张治疗,持续3个月。

结果

平均(范围)随访29(12 - 37)个月;19例出现早期狭窄的患者接受了局部类固醇扩张治疗。治疗后,在定期6 - 12个月的评估中,14条新尿道可通过最小10F的探子。5例对治疗无反应的患者狭窄持续存在;其中1例出现憩室,2例出现瘘管。所有有永久性并发症的患者均再次手术。使用0.05%倍他米松乳膏治疗的患者均未出现不良反应。

结论

尿道下裂修复术后早期对新尿道进行校准和扩张是早期发现和治疗尿道口狭窄的有效方法。新设计的探子使校准/扩张对患者来说不那么痛苦且更容易接受。局部皮质类固醇可改善瘢痕弹性,有助于扩张并防止尿道口狭窄的形成。

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