Cappelleri Joseph C, Althof Stanley E, Siegel Richard L, Stecher Vera J, Tseng Li-Jung, Duttagupta Sandeep
Pfizer Inc, Global Research & Development, Groton, CT 06340-8030, USA.
Value Health. 2005 Nov-Dec;8 Suppl 1:S54-60. doi: 10.1111/j.1524-4733.2005.00072.x.
Research is lacking on the correlation between treatment satisfaction and confidence, self-esteem, and relationships for men receiving treatment for erectile dysfunction (ED). We sought to correlate scores between the validated Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) index and the validated Self-Esteem And Relationship (SEAR) questionnaire following treatment with sildenafil citrate (VIAGRA).
This study was based on an open-label, flexible-dose trial of 93 sildenafil-naive patients with ED. Pearson correlation coefficients between EDITS index and SEAR questionnaire scores, each of which can range from 0 to 100 (most favorable), were calculated at end of treatment (EOT). An analysis of covariance model was applied to associate changes from baseline to EOT in SEAR scores with EDITS score at EOT, controlling for baseline SEAR score.
Significant and sizable Pearson's correlations between SEAR and EDITS scores (P < or = 0.0001; range: 0.49-0.84) were observed. A 10-point higher EDITS scores at EOT corresponded to a significant and tangible average improvement in SEAR scores from baseline to EOT (P < or = 0.0001; range: 6.6-8.7). Average SEAR scores at EOT were markedly different between patients with greater treatment satisfaction at EOT (EDITS score > or = median EDITS score of 88.6; n = 50) and those with lesser treatment satisfaction at EOT (EDITS score <88.6; n = 43).
The data add to the validity of the SEAR questionnaire, suggest a tangible relationship between treatment satisfaction and psychosocial benefit among men with ED treated with sildenafil, and highlight the importance of assessing the psychosocial impact of ED in men undergoing treatment.
目前缺乏关于接受勃起功能障碍（ED）治疗的男性的治疗满意度与自信、自尊及人际关系之间相关性的研究。我们试图在使用枸橼酸西地那非（万艾可）治疗后，将经过验证的治疗满意度勃起功能障碍量表（EDITS）指数得分与经过验证的自尊与关系（SEAR）问卷得分进行关联分析。
本研究基于一项针对93例未使用过西地那非的ED患者的开放标签、灵活剂量试验。在治疗结束时（EOT）计算EDITS指数与SEAR问卷得分之间的Pearson相关系数，二者得分范围均为0至100（最有利情况）。应用协方差分析模型，将SEAR得分从基线到EOT的变化与EOT时的EDITS得分相关联，并对基线SEAR得分进行控制。
观察到SEAR与EDITS得分之间存在显著且较大的Pearson相关性（P≤0.0001；范围：0.49 - 0.84）。EOT时EDITS得分每高10分，对应着SEAR得分从基线到EOT有显著且明显的平均改善（P≤0.0001；范围：6.6 - 8.7）。EOT时，治疗满意度较高的患者（EDITS得分≥88.6的中位数；n = 50）与治疗满意度较低的患者（EDITS得分＜88.6；n = 43）之间的平均SEAR得分存在显著差异。
这些数据增加了SEAR问卷的有效性，表明在接受西地那非治疗的ED男性中，治疗满意度与心理社会获益之间存在明显关系，并强调了评估ED对接受治疗男性心理社会影响的重要性。
