11β-羟基类固醇脱氢酶1型与6-磷酸己糖脱氢酶之间的协同作用基于内质网腔中的一个共同吡啶核苷酸池。
Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum.
作者信息
Czegle Ibolya, Piccirella Simona, Senesi Silvia, Csala Miklós, Mandl József, Bánhegyi Gábor, Fulceri Rosella, Benedetti Angelo
机构信息
The Endoplasmic Reticulum Research Group of the Hungarian Academy of Sciences and Semmelweis University, 1444 Budapest, Hungary.
出版信息
Mol Cell Endocrinol. 2006 Mar 27;248(1-2):24-5. doi: 10.1016/j.mce.2005.10.018. Epub 2005 Dec 6.
11Beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) is a NADP(H)-dependent oxidoreductase of the ER lumen, which may have an important role in the pathogenesis of metabolic syndrome. Here, the functional coupling of 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase (H6PDH) was investigated in rat liver microsomal vesicles. The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11betaHSD1 and H6PDH based on their co-localization and the mutual generation of cofactors for each other.
11β-羟基类固醇脱氢酶1型（11βHSD1）是一种内质网腔中依赖烟酰胺腺嘌呤二核苷酸磷酸（NADP(H)）的氧化还原酶，其可能在代谢综合征的发病机制中发挥重要作用。在此，我们在大鼠肝微粒体囊泡中研究了11β-羟基类固醇脱氢酶1型与6-磷酸己糖脱氢酶（H6PDH）的功能偶联。结果表明，肝内质网中存在一个独立的腔内吡啶核苷酸池，并且基于11βHSD1和H6PDH的共定位以及它们相互为对方生成辅因子，二者之间存在密切合作。
Zotero 插件