Yucel Aykan, Noyan Volkan, Sagsoz Nevin
Kirikkale University, School of Medicine, Department of Gynecology and Obstetrics, Kirikkale, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2006 May 1;126(1):81-6. doi: 10.1016/j.ejogrb.2005.11.012. Epub 2005 Dec 7.
The aim of the study was to compare the body fat distribution of women with polycystic ovary syndrome (PCOS) with age and body mass index matched healthy controls and to investigate if androgens and insulin resistance associated with fat distribution.
Thirty-three PCOS and 21 age and body mass index (BMI) matched healthy control women were evaluated in terms of body fat distribution with dual X-ray absorpsiometry (DEXA). Blood samples were obtained for follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, prolactin, thyroid stimulating hormone (TSH), dehydroepiandrosterone-sulfate (DHEA-S), free testosterone, sex hormone binding globulin (SHBG), insulin and glucose levels. A 75 g 2 h glucose tolerance test was performed for each woman. Insulin resistance was estimated by fasting insulin level, fasting glucose/insulin ratio and 75 g 2 h glucose tolerance test. The Student's t-test and Mann-Whitney U-test were used to compare the groups. Pearson and Spearman rank correlation coefficients were calculated for normally and nonnormally distributed variables, respectively. Partial correlation coefficients were calculated using age and BMI as covariates.
Fat mass in trunk and arms were significantly higher in patients with PCOS (p < 0.043 and 0.036, respectively). The ratio of fat mass in trunk to fat mass in legs were significantly higher in patients with PCOS (p < 0.011). Free testosterone was found to be positively correlated with fat mass in arms (r = 0.401, p < 0.05). There was still significant correlation between free testosterone and fat mass in arms (r = 0.5964, p < 0.05) after controlling for age and BMI.
Free testosterone level is positively correlated with the fat mass in arms in women with PCOS.
本研究旨在比较多囊卵巢综合征（PCOS）女性与年龄及体重指数相匹配的健康对照者的体脂分布情况，并探讨雄激素和胰岛素抵抗与脂肪分布是否相关。
采用双能X线吸收法（DEXA）对33例PCOS女性和21例年龄及体重指数（BMI）相匹配的健康对照女性进行体脂分布评估。采集血样检测促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇、催乳素、促甲状腺激素（TSH）、硫酸脱氢表雄酮（DHEA-S）、游离睾酮、性激素结合球蛋白（SHBG）、胰岛素和血糖水平。对每位女性进行75g 2小时葡萄糖耐量试验。通过空腹胰岛素水平、空腹血糖/胰岛素比值和75g 2小时葡萄糖耐量试验评估胰岛素抵抗。采用学生t检验和曼-惠特尼U检验比较各组。分别对正态分布和非正态分布变量计算Pearson和Spearman等级相关系数。以年龄和BMI作为协变量计算偏相关系数。
PCOS患者躯干和手臂的脂肪量显著更高（分别为p < 0.043和0.036）。PCOS患者躯干脂肪量与腿部脂肪量的比值显著更高（p < 0.011）。发现游离睾酮与手臂脂肪量呈正相关（r = 0.401，p < 0.05）。在控制年龄和BMI后，游离睾酮与手臂脂肪量之间仍存在显著相关性（r = 0.5964，p < 0.05）。
PCOS女性的游离睾酮水平与手臂脂肪量呈正相关。
