Huang Timothy Y, DerMardirossian Céline, Bokoch Gary M
The Scripps Research Institute, Departments of Immunology and Cell Biology, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.
Curr Opin Cell Biol. 2006 Feb;18(1):26-31. doi: 10.1016/j.ceb.2005.11.005. Epub 2005 Dec 7.
Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin. These cofilin phosphatases are unrelated in sequence and regulatory properties, each potentially providing a unique mechanism for cofilin activation under varying biological circumstances.
丝切蛋白是一种普遍存在的肌动蛋白结合因子，是真核生物中肌动蛋白丝重组所必需的。丝切蛋白的去磷酸化使其具有肌动蛋白切断和解聚活性，并驱动细胞定向运动，从而为肌动蛋白重组提供了一种简单的磷酸化调节机制。迄今为止，已鉴定出两种丝切蛋白特异性磷酸酶：弹弓蛋白和时相蛋白。这些丝切蛋白磷酸酶在序列和调节特性上无关，每种磷酸酶都可能在不同的生物学环境下为丝切蛋白激活提供独特的机制。
