先天性食管闭锁一期修复术后22年发生食管腺癌。

Development of an adenocarcinoma of the esophagus 22 years after primary repair of a congenital atresia.

作者信息

Pultrum Bareld B, Bijleveld Charles M, de Langen Zacharias J, Plukker John Th M

机构信息

Department of Surgical Oncology, University Medical Center Groningen (UMCG), 9700 RB Groningen, The Netherlands.

出版信息

J Pediatr Surg. 2005 Dec;40(12):e1-4. doi: 10.1016/j.jpedsurg.2005.08.042.

DOI:10.1016/j.jpedsurg.2005.08.042

PMID:16338286

Abstract

Esophageal cancer development after previous atresia repair is extremely rare in young patients. We present the clinical course of a patient who developed an adenocarcinoma of the esophagus at the age of 22 years, after repair of a tracheoesophageal fistula with esophageal atresia in the neonatal period. She developed a stricture of the esophageal anastomosis requiring frequent dilatations. Six years after an antireflux procedure because of a difficult treatable severe gastroesophageal reflux, an advanced adenocarcinoma was detected at the site of the end-to-end anastomosis of the previous atresia.

摘要

既往食管闭锁修复术后发生食管癌在年轻患者中极为罕见。我们报告了一名患者的临床病程，该患者在新生儿期行食管闭锁合并气管食管瘘修复术后，22岁时发生了食管腺癌。她出现了食管吻合口狭窄，需要频繁扩张。在因难治性严重胃食管反流行抗反流手术后六年，在前次闭锁端端吻合部位检测到进展期腺癌。