重型β地中海贫血输血周期中的非转铁蛋白结合铁

Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major.

作者信息

Grosse Regine, Lund Ulrike, Caruso Vincenzo, Fischer Roland, Janka Gritta E, Magnano Carmelo, Engelhardt Rainer, Dürken Matthias, Nielsen Peter

机构信息

University Medical Center Hamburg-Eppendorf, Department of Pediatric Hematology/Oncology, Martinistr. 52, Hamburg D-20246, Germany.

出版信息

Ann N Y Acad Sci. 2005;1054:429-32. doi: 10.1196/annals.1345.074.

DOI:10.1196/annals.1345.074

PMID:16339692

Abstract

Serum non-transferrin-bound iron (NTBI) levels assessed at arbitrary time points during transfusion cycles may not be representative if NTBI is undergoing significant changes during transfusion cycles. In 15 patients with beta-thalassemia major (age: 21 +/- 6 years, liver iron concentration: 2200 +/- 1200 microg/g-liver), NTBI and other hematologic parameters (transferrin saturation, transferrin receptor) were measured weekly. The largest variation of NTBI levels between individual patients was observed at midcycle. For long-term monitoring of NTBI levels, a particular time point relative to the last blood transfusion should be selected for blood drawing.

摘要

如果在输血周期中非转铁蛋白结合铁（NTBI）水平发生显著变化，那么在输血周期中任意时间点评估的血清NTBI水平可能不具有代表性。在15例重型β地中海贫血患者（年龄：21±6岁，肝脏铁浓度：2200±1200μg/g肝脏）中，每周测量NTBI及其他血液学参数（转铁蛋白饱和度、转铁蛋白受体）。个体患者之间NTBI水平的最大差异出现在周期中期。为了长期监测NTBI水平，应选择相对于最后一次输血的特定时间点进行采血。