Chitnis S, Chitnis V, Hemvani N, Chitnis D S
Department of Microbiology and Immunology, Choithram Hospital and Research Centre, Indore, India.
Chemotherapy. 2006;52(1):43-5. doi: 10.1159/000090243. Epub 2005 Dec 9.
Growing multiple drug resistance among gram-negative bacilli among hospitalized patients is a serious therapeutic problem, and the aim of the study was to assess the situation in our hospital.
Antimicrobial susceptibility testing with the disk method was carried out on 1,533 isolates of gram-negative bacilli from urine, pus, body fluid and blood from hospitalized patients.
Seventeen percent of isolates were susceptible only to meropenem and either to piperacillin + tazobactam, to cefoperazone + sulbactam or to both. Eleven percent of isolates were susceptible only to meropenem and 6% were resistant to all antimicrobial agents including meropenem.
Growing multiple drug resistance among gram-negative bacilli in hospital practice demands a rigid antibiotic policy and strict infection control measures.
住院患者中革兰氏阴性杆菌多重耐药性不断增加是一个严重的治疗问题，本研究旨在评估我院的情况。
采用纸片法对1533株来自住院患者尿液、脓液、体液和血液的革兰氏阴性杆菌进行药敏试验。
17%的分离株仅对美罗培南敏感，且对哌拉西林+他唑巴坦、头孢哌酮+舒巴坦其中之一或两者均敏感。11%的分离株仅对美罗培南敏感，6%的分离株对包括美罗培南在内的所有抗菌药物耐药。
医院实际工作中革兰氏阴性杆菌多重耐药性不断增加，需要严格的抗生素政策和严格的感染控制措施。
