Güven Mehmet, Demir Deniz, Süoğlu Yusufhan, Emin Haluk, Kiyak Erkan, Enöz Murat
Department of Otolaryngology, Medicine Faculty of Gaziosmanpaşa University, Tokat, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2005;15(1-2):22-9.
We investigated the long-term results of autologous fat injections for unilateral vocal cord paralysis and laryngofissure and cordectomy defects.
We evaluated the efficacy of autologous fat injections in 21 patients (16 males, 5 females; mean age 57 years; range 24 to 72 years) with unilateral vocal cord paralysis (n=11) and cordectomy defects (n=10) in the light of computed acoustic analysis, phonatory functions, and videolaryngostroboscopic findings and the effect of injections on swallowing. The mean follow-up was 14 months (range 10 to 22 months).
Voice quality improved in 14 patients. Glottic insufficiency recurred in three patients in the early period, and in two patients in the late period. Phonatory functions showed significant improvement in all parameters except for jitter and functional interference (p<0.05). Videolaryngostroboscopy showed significant improvement in glottic closure, but mucosal waves remained unchanged. Of 18 patients with swallowing disorders, aspiration symptoms improved in 15 patients. Patients with unilateral vocal cord paralysis had better results compared to those with cordectomy defects.
Autologous fat injections may be considered effective in patients with cordectomy defects or unilateral vocal cord paralysis.
我们研究了自体脂肪注射治疗单侧声带麻痹以及喉裂开和声带切除术缺损的长期效果。
我们根据计算机声学分析、发声功能以及视频喉镜频闪观察结果，评估了21例患者（16例男性，5例女性；平均年龄57岁；年龄范围24至72岁）的自体脂肪注射疗效，这些患者包括单侧声带麻痹（n = 11）和声带切除术缺损（n = 10），并评估了注射对吞咽的影响。平均随访时间为14个月（范围10至22个月）。
14例患者的嗓音质量得到改善。3例患者早期出现声门闭合不全复发，2例患者晚期出现复发。除抖动和功能干扰外，所有参数的发声功能均有显著改善（p<0.05）。视频喉镜频闪观察显示声门闭合有显著改善，但黏膜波保持不变。18例有吞咽障碍的患者中，15例患者的误吸症状有所改善。与声带切除术缺损患者相比，单侧声带麻痹患者的效果更好。
自体脂肪注射对于声带切除术缺损或单侧声带麻痹患者可能是有效的。
