Bulut Erdoğan, Yağiz Recep, Taş Abdullah, Uzun Cem, Yildirim Cetin, Kaymak Kadir, Karasalioğlu Ahmet R
Department of Otolaryngology, Medicine Faculty of Trakya University, Edirne, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2005;15(3-4):70-7.
This experimental study was performed to evaluate the protective effect of magnesium on amikacin ototoxicity.
Twenty-seven guinea pigs (54 ears) with normal auropalpebral reflexes and otomicroscopic examination, auditory brain stem responses (ABR), and transient evoked otoacoustic emissions (TEOAE) were randomly divided into four groups to receive amikacin once 15 mg/kg daily (group 1 and 3) and twice 7.5 mg/kg daily (group 2 and 4) for seven days. Groups 3 and 4 were administered oral MgCl an hour after amikacin use at a dose of 39 mmol/l and 19.5 mmol/l, respectively, for seven days. Otomicroscopic examination, ABR and TEOAE measurements were repeated on the third, fifth, and seventh days.
Compared to group 1, decreases in TEOAE amplitudes and reproducibility and increases in ABR thresholds were significant in group 2 (p<0.05). However, in groups 3 and 4, TEOAE amplitudes remained unchanged, or even increased and the reproducibility of TEOAE responses and ABR thresholds showed no significant changes (p>0.05).
Our data show that oral magnesium may play a protective role on amikacin ototoxicity.
本实验研究旨在评估镁对阿米卡星耳毒性的保护作用。
27只豚鼠（54只耳），耳睑反射、耳镜检查、听性脑干反应（ABR）及瞬态诱发耳声发射（TEOAE）均正常，随机分为四组，连续7天每天一次给予15mg/kg阿米卡星（第1组和第3组）或每天两次给予7.5mg/kg阿米卡星（第2组和第4组）。第3组和第4组在使用阿米卡星1小时后分别口服39mmol/l和19.5mmol/l的MgCl，持续7天。在第3、5和7天重复进行耳镜检查、ABR和TEOAE测量。
与第1组相比，第2组TEOAE波幅降低、可重复性下降及ABR阈值升高均有统计学意义（p<0.05）。然而，第3组和第4组TEOAE波幅保持不变，甚至升高，TEOAE反应的可重复性和ABR阈值无显著变化（p>0.05）。
我们的数据表明口服镁可能对阿米卡星耳毒性起到保护作用。
