Ruttmann E, Naether O
Arzt für Frauenheilkunde, Hamburg.
Geburtshilfe Frauenheilkd. 1992 Jun;52(6):369-71. doi: 10.1055/s-2007-1023770.
Within five years, a patient had five abortions and one biochemical pregnancy with two different partners. After the fourth pregnancy, she underwent a heterologous immune stimulation. The karyotypes of all three partners were normal. On her first visit, a subclinical hypothyroidism was detected and substitution with 50 micrograms L-thyroxine was started. Before further endocrinological, virological, or anatomical investigation, the patient conceived spontaneously for the seventh time. Even though the beta-HCG-levels rose adequately and the sonographic development was according to time, serum-progesterone could not be detected before the eighth week of pregnancy and sufficient levels were found from the 15th week onwards. The patient received a hormonal substitution therapy with Gravibinon 250 mg i.m. twice a week up to the 15th week of gestation. She finally delivered a 3800 g healthy boy.
五年内，一名患者与两名不同伴侣发生了五次流产和一次生化妊娠。第四次怀孕后，她接受了异源免疫刺激。所有三名伴侣的染色体核型均正常。首次就诊时，检测到亚临床甲状腺功能减退，并开始用50微克左甲状腺素进行替代治疗。在进一步进行内分泌、病毒学或解剖学检查之前，患者第七次自然受孕。尽管β-HCG水平充分升高且超声检查发育正常，但在怀孕第八周前未检测到血清孕酮，从第15周起发现孕酮水平充足。患者在妊娠第15周前每周两次接受250毫克黄体酮肌肉注射的激素替代治疗。她最终产下了一个体重3800克的健康男婴。
