Bickel A, Kornhuber J, Maihöfner C, Ropohl A
Pharmacopsychiatry. 2005 Nov;38(6):327-8. doi: 10.1055/s-2005-916190.
Abnormal signal transmission in central serotonergic pathways is supposed to play an important role in the pathogenesis of migraine and major depression. We report on a patient, who was treated during an episode of depression with the selective serotonin reuptake inhibitor (SSRI) sertraline and developed frequent migraine attacks under this therapeutical regime. Single migraine attacks were treated successfully with triptanes. Although SSRIs may be beneficial for migraine prophylaxis at long term administration, this case suggests that acute administration of SSRIs in migraineurs may include the risk of worsening migraine.
中枢5-羟色胺能通路的异常信号传递被认为在偏头痛和重度抑郁症的发病机制中起重要作用。我们报告了一名患者，其在抑郁症发作期间接受选择性5-羟色胺再摄取抑制剂（SSRI）舍曲林治疗，并在此治疗方案下出现频繁的偏头痛发作。单次偏头痛发作使用曲坦类药物成功治疗。虽然长期服用SSRI可能对偏头痛预防有益，但该病例表明，偏头痛患者急性服用SSRI可能存在使偏头痛恶化的风险。
