Baba Yasuhiko, Putzke John D, Whaley Nathaniel R, Wszolek Zbigniew K, Uitti Ryan J
Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA.
Mov Disord. 2006 May;21(5):689-92. doi: 10.1002/mds.20769.
We examined sex-based differences in phenotypic expression among a consecutive clinical series of 121 individuals diagnosed with probable progressive supranuclear palsy (PSP). For both men (44%) and women (56%), the age at symptomatic onset (66.2 and 68.5 years, respectively) and disease duration (4.6 and 4.3 years, respectively) were similar. The overwhelming majority of sex-based comparisons showed no significant difference on a variety of demographic, historical, and clinical characteristics, as well as measures of disease progression. The only differences observed were that men had significantly worse tremor as measured by the Unified Parkinson's Disease Rating Scale tremor subscore (0.9 for men and 0.3 for women, P<0.01) and men had a significantly higher mean body mass index (BMI; 28.2 for men and 25.1 for women, P=0.01), although these differences were not significant after Bonferroni correction. In general, the disease phenotype was similar between men and women, suggesting that sex may have little or no influence on the development, expression, or progression of the PSP phenotype.
我们在一个连续的临床系列中，对121名被诊断为可能的进行性核上性麻痹（PSP）的个体进行了表型表达的性别差异研究。对于男性（44%）和女性（56%），症状出现时的年龄（分别为66.2岁和68.5岁）以及病程（分别为4.6年和4.3年）相似。绝大多数基于性别的比较在各种人口统计学、病史和临床特征以及疾病进展指标方面均未显示出显著差异。观察到的唯一差异是，根据统一帕金森病评定量表震颤亚评分衡量，男性的震颤明显更严重（男性为0.9，女性为0.3，P<0.01），并且男性的平均体重指数（BMI）显著更高（男性为28.2，女性为25.1，P=0.01），尽管在Bonferroni校正后这些差异并不显著。总体而言，男性和女性之间的疾病表型相似，这表明性别可能对PSP表型的发生、表达或进展几乎没有影响。
