Ueda Misako, Inaba Masaaki, Kumeda Yasuro, Nagasaki Toshiki, Hiura Yoshikazu, Tahara Hideki, Onoda Naoyoshi, Ishikawa Tetsuro, Nishizawa Yoshiki
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
Clin Endocrinol (Oxf). 2005 Dec;63(6):657-62. doi: 10.1111/j.1365-2265.2005.02397.x.
We investigated the clinical usefulness of thyroid blood-flow measurement in predicting relapse of Graves' disease (GD) in comparison with known risk factors for GD relapse.
Thyroid blood flow was measured in pulsed Doppler mode at the inferior thyroid artery (ITA), and the peak systolic velocity (PSV) calculated.
ITA-PSV was measured in euthyroid GD patients (n = 79) immediately before withdrawal of anti-thyroid drug (ATD) and in healthy subjects (n = 17).
In the 79 euthyroid GD patients, the values of free triiodothyronine (FT3), TSH receptor autoantibody (TRAb), ITA-PSV and thyroid volume were significantly higher in the relapse group (n = 40) than in the nonrelapse group (n = 39) and the Youden index of ITA-PSV was significantly higher than that of FT3, TSH, TRAb and vascular endothelial growth factor (VEGF).
ITA-PSV may assist in the prediction of early GD relapse after ATD withdrawal.
与已知的Graves病（GD）复发风险因素相比，我们研究了甲状腺血流测量在预测GD复发中的临床实用性。
采用脉冲多普勒模式在下甲状腺动脉（ITA）测量甲状腺血流，并计算收缩期峰值速度（PSV）。
在79例甲状腺功能正常的GD患者停用抗甲状腺药物（ATD）前即刻测量ITA-PSV，另外对17名健康受试者也进行了测量。
在79例甲状腺功能正常的GD患者中，复发组（n = 40）的游离三碘甲状腺原氨酸（FT3）、促甲状腺激素受体自身抗体（TRAb）、ITA-PSV和甲状腺体积值显著高于未复发组（n = 39），且ITA-PSV的约登指数显著高于FT3、促甲状腺激素（TSH）、TRAb和血管内皮生长因子（VEGF）。
ITA-PSV可能有助于预测ATD停用后GD的早期复发。
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