Viallet Norbert R, Blakley Brian W, Begleiter Asher, Leith Marsha K
Department of Otolaryngology, University of Manitoba, Winnipeg, MB.
J Otolaryngol. 2005 Dec;34(6):371-3. doi: 10.2310/7070.2005.34602.
To study the effect of cis-diamminedichloroplatinum (CDDP) on FADU squamous cell carcinoma cells in a nude mouse model and to determine the effect of sodium thiosulphate (STS) on CDDP activity.
CD1 nude mice were inoculated with FADU tumour cells to both flanks. They were then randomized to four treatment groups: control, CDDP only, STS only, or CDDP and STS. Tumour growth was measured using calipers and charted at 3-day intervals.
Tumour volumes were calculated as an ellipsoid and charted against time.
CDDP inhibited FADU tumour cell growth compared with saline controls (p < .005). The addition of STS did not inhibit the CDDP activity when compared with CDDP-alone activity (p = .989). Compared with saline control solution, STS alone also inhibited tumour growth significantly (p < .005).
在裸鼠模型中研究顺二氯二氨铂（CDDP）对FADU鳞状细胞癌细胞的作用，并确定硫代硫酸钠（STS）对CDDP活性的影响。
将FADU肿瘤细胞接种到CD1裸鼠的双侧胁腹。然后将它们随机分为四个治疗组：对照组、仅用CDDP组、仅用STS组或CDDP与STS组。使用卡尺测量肿瘤生长情况，并每隔3天记录一次。
肿瘤体积按椭球体计算，并根据时间进行记录。
与生理盐水对照组相比，CDDP抑制了FADU肿瘤细胞的生长（p < 0.005）。与单独使用CDDP的活性相比，添加STS并未抑制CDDP的活性（p = 0.989）。与生理盐水对照溶液相比，单独使用STS也显著抑制了肿瘤生长（p < 0.005）。
