Benson Blaine E, Spyker Daniel A, Troutman William G, Watson William A
New Mexico Poison and Drug Information Center and University of New Mexico College of Pharmacy, Albuquerque, 87131, USA.
Toxicol Appl Pharmacol. 2006 Jun 1;213(2):145-51. doi: 10.1016/j.taap.2005.10.009. Epub 2005 Dec 15.
The toxic and lethal doses of clonidine in children are unclear. This study was designed to determine whether data from the American Association of Poison Control Centers Toxic Exposure Surveillance System (TESS) could be utilized to determine a dose-response relationship for pediatric clonidine exposure.
3,458 single-substance clonidine exposures in children <6 years of age reported to TESS from January 2000 through December 2003 were examined. Dose ingested, age, and medical outcome were available for 1550 cases. Respiratory arrest cases (n = 8) were classified as the most severe of the medical outcome categories (Arrest, Major, Moderate, Mild, and No effect). Exposures reported as a "taste or lick" (n = 51) were included as a dose of 1/10 of the dosage form involved. Dose ranged from 0.4 to 1980 (median 13) microg/kg. Weight was imputed based on a quadratic estimate of weight for age. Dose certainty was coded as exact (26% of cases) or not exact (74%). Medical outcome (response) was examined via logistic regression using SAS JMP (release 5.1).
The logistic model describing medical outcome (P < 0.0001) included Log dose/kg (P = 0.0000) and Certainty (P = 0.045).
TESS data can provide the basis for a statistically sound description of dose-response for pediatric clonidine poisoning exposures.
可乐定在儿童中的中毒剂量和致死剂量尚不清楚。本研究旨在确定美国毒物控制中心协会毒物暴露监测系统（TESS）的数据是否可用于确定儿童可乐定暴露的剂量-反应关系。
对2000年1月至2003年12月向TESS报告的6岁以下儿童3458例单物质可乐定暴露病例进行了检查。1550例病例提供了摄入剂量、年龄和医疗结果。呼吸骤停病例（n = 8）被归类为医疗结果类别中最严重的（骤停、严重、中度、轻度和无影响）。报告为“尝或舔”的暴露（n = 51）被视为所涉剂型剂量的1/10。剂量范围为0.4至1980（中位数13）微克/千克。根据年龄体重的二次估计推算体重。剂量确定性编码为精确（26%的病例）或不精确（74%）。使用SAS JMP（版本5.1）通过逻辑回归检查医疗结果（反应）。
描述医疗结果的逻辑模型（P < 0.0001）包括每千克剂量对数（P = 0.0000）和确定性（P = 0.045）。
TESS数据可为儿童可乐定中毒暴露的剂量-反应的统计学合理描述提供依据。
