Ranganath C
Center for Neuroscience and Department of Psychology, University of California at Davis, 1544 Newton Court, Davis, CA 95616, USA.
Neuroscience. 2006 Apr 28;139(1):277-89. doi: 10.1016/j.neuroscience.2005.06.092. Epub 2005 Dec 15.
Humans have an extraordinary ability to maintain and manipulate visual image information in the absence of perceptual stimulation. The neural substrates of visual working memory have been extensively researched, but there have been few attempts to integrate these findings into a model of how different cortical areas interact to form and maintain visual memories. In this paper, I review findings from neurophysiological, neuropsychological, and neuroimaging studies of visual working memory in human and nonhuman primates. These data support a model in which visual working memory operations rely on activation of object representations in inferior temporal cortex, via top-down feedback from neocortical areas in the prefrontal and medial temporal cortex, and also from the hippocampus.
人类具有在没有感知刺激的情况下维持和处理视觉图像信息的非凡能力。视觉工作记忆的神经基础已得到广泛研究，但很少有人尝试将这些发现整合到一个关于不同皮质区域如何相互作用以形成和维持视觉记忆的模型中。在本文中，我回顾了人类和非人类灵长类动物视觉工作记忆的神经生理学、神经心理学和神经影像学研究的结果。这些数据支持了一个模型，即视觉工作记忆操作依赖于颞下皮质中物体表征的激活，这是通过前额叶和内侧颞叶皮质以及海马体的新皮质区域的自上而下反馈实现的。
