新型氯乙胺铂配合物的合成、表征及抗肿瘤活性
Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes.
作者信息
Khokhar A R, Xu Q, Newman R A, Kido Y, Siddik Z H
机构信息
Department of Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston 77030.
出版信息
J Inorg Biochem. 1992 Feb 15;45(3):211-9. doi: 10.1016/0162-0134(92)80046-x.
A series of cis-bis-(2-chloroethylamine)platinum(II) and platinum(IV) complexes were synthesized and characterized by elemental analysis, IR, and 1H and 195Pt NMR spectroscopic techniques. Complexes were tested in vitro against murine L1210 leukemia and human ovarian A2780 cell lines and in vivo against the L1210 leukemia model. Some of these complexes showed excellent antitumor activity in both systems. However, all were inactive against cisplatin-resistant A2780/CP cells.
合成了一系列顺式-双-(2-氯乙胺)铂(II)和铂(IV)配合物，并通过元素分析、红外光谱、1H和195Pt核磁共振光谱技术对其进行了表征。这些配合物在体外针对小鼠L1210白血病细胞系和人卵巢A2780细胞系进行了测试，并在体内针对L1210白血病模型进行了测试。其中一些配合物在这两个系统中均表现出优异的抗肿瘤活性。然而，所有配合物对顺铂耐药的A2780/CP细胞均无活性。
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