固定化麦角菌在半连续和连续培养中长期生产麦角肽。
Long-Term Production of Ergot Peptides by Immobilized Claviceps purpurea in Semicontinuous and Continuous Culture.
机构信息
Institut für Mikrobiologie, Universität Münster, Corrensstrasse 3, D-4400 Münster, Germany.
出版信息
Appl Environ Microbiol. 1993 Jul;59(7):2029-33. doi: 10.1128/aem.59.7.2029-2033.1993.
Abstract
The semicontinuous and continuous production of pharmaceutically useful ergot peptides with immobilized Claviceps purpurea could be demonstrated. A key aspect was the presence of high concentrations of CaCl(2) (96.9 mM) to give marked prolongation of the productive phase, and cultivation in a bubble column reactor became possible. Restriction of the phosphate supply avoided an otherwise problematic massive increase of outgrowing hyphae.
摘要
已经证明可以用固定化麦角菌连续半连续生产药用麦角肽。一个关键的方面是存在高浓度的氯化钙（96.9 mM），以显著延长生产阶段，并且可以在鼓泡塔反应器中进行培养。限制磷酸盐的供应可以避免否则会出现的大量长出菌丝的问题。
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