Forrest L J, Dodge R K, Page R L, Heidner G L, McEntee M C, Novotney C A, Thrall D E
College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
J Nucl Med. 1992 Aug;33(8):1542-7.
Parameters that predict tumor aggressiveness or response to therapy are potentially useful in selecting the most appropriate treatment. In theory, the biologic aggressiveness of an untreated bone tumor may be reflected in bone scan parameters. The purpose of this study was to assess the usefulness of bone scintigraphy as a predictive indicator of subsequent metastasis in 25 dogs with primary osteosarcoma. Dogs received radiotherapy and/or intra-arterial cisplatin prior to limb-sparing surgery. Quantitative bone scintigraphy of the tumor was performed prior to treatment (25 dogs) and following treatment but prior to limb-sparing surgery (22 dogs). All dogs developed metastasis at a median time of 202 days (range, 41-444 days) after initiation of treatment. A statistically significant relationship was identified between time to metastasis and: (1) the radiographic tumor area, (2) the pretreatment ratio of mean counts per pixel in tumor-to-adjacent nontumor bone (T/NTT), and (3) the pre:post-treatment T/NTT. Larger tumor area and high pretreatment tumor activity were associated with earlier metastasis. Tumors characterized by greater decreases in scintigraphic uptake after treatment were associated with earlier metastasis. These data suggest that osteosarcomas with high pretreatment mean counts per pixel signify aggressive tumors subject to early metastasis.
预测肿瘤侵袭性或对治疗反应的参数在选择最合适的治疗方法时可能很有用。理论上，未经治疗的骨肿瘤的生物学侵袭性可能反映在骨扫描参数中。本研究的目的是评估骨闪烁显像作为25只患有原发性骨肉瘤的犬后续转移的预测指标的有用性。在保肢手术前，犬接受了放疗和/或动脉内顺铂治疗。在治疗前（25只犬）以及治疗后但在保肢手术前（22只犬）对肿瘤进行了定量骨闪烁显像。所有犬在开始治疗后的中位时间202天（范围41 - 444天）出现转移。转移时间与以下因素之间存在统计学上的显著关系：（1）放射影像学肿瘤面积，（2）治疗前肿瘤与相邻非肿瘤骨每像素平均计数的比率（T/NTT），以及（3）治疗前与治疗后的T/NTT。较大的肿瘤面积和较高的治疗前肿瘤活性与较早转移相关。治疗后骨闪烁显像摄取减少幅度更大的肿瘤与较早转移相关。这些数据表明，治疗前每像素平均计数高的骨肉瘤表明是易发生早期转移的侵袭性肿瘤。
