Obeid G, Zhang X, Wang X
Department of Oral and Maxillofacial Surgery, Washington Hospital Center, Washington, DC 20010.
J Oral Maxillofac Surg. 1992 Aug;50(8):843-9; discussion 849-50. doi: 10.1016/0278-2391(92)90276-6.
The purpose of this study was to determine the effect of ibuprofen on the healing and remodeling of bone and cartilage in the temporomandibular joint of the rabbit. Forty-two rabbits were operated on to create a groove and a hole in the articular surface of both the right and left mandibular condyles. Following surgery, the animals were divided into three groups. Group A (12 rabbits) was used as a control and the animals did not receive any medication. Group B (15 rabbits) was given a daily dose of 17 mg/kg of ibuprofen. Group C (15 rabbits) was given a daily dose of 34 mg/kg of ibuprofen. All animals were killed after 4 weeks. The 84 condyles were examined clinically and histologically. Statistical analysis showed a highly significant difference in the healing of bone and cartilage between groups A and C (P less than .01) and a significant difference between groups A and B (P less than .05). The results of this study indicate that ibuprofen has an adverse effect on the healing of bone and cartilage in the temporomandibular joint of the rabbit.
本研究的目的是确定布洛芬对兔颞下颌关节骨和软骨愈合及重塑的影响。对42只兔子进行手术，在左右下颌髁突的关节表面制造一个凹槽和一个洞。手术后，将动物分为三组。A组（12只兔子）作为对照组，动物不接受任何药物治疗。B组（15只兔子）每天给予17mg/kg的布洛芬剂量。C组（15只兔子）每天给予34mg/kg的布洛芬剂量。4周后处死所有动物。对84个髁突进行临床和组织学检查。统计分析显示，A组和C组之间骨和软骨愈合存在高度显著差异（P小于0.01），A组和B组之间存在显著差异（P小于0.05）。本研究结果表明，布洛芬对兔颞下颌关节骨和软骨的愈合有不良影响。
