Pansegrouw D
S Afr Med J. 1975 Mar 1;49(9):317-8.
The early effects of phenobarbitone, theophylline, thyroxine and of combinations of these drugs, on rat liver microsomal aniline hydroxylase activity, were studied, and the results were compared with the effect of phenobarbitone on purified c-AMP-phosphodiesterase in vitro. The stimulatory effect of phenobarbitone on hepatic microsomal aniline hydroxylase activity was found to be simulated by theophylline, and also by thyroxine. When phenobarbitone and thyroxine were used, the effect was approximately equal to the sum of the individual effects, but no summation was seen when phenobarbitone and theophylline were used. Phenobarbitone caused an inhibition of c-AMP-phosphodiesterase activity in vitro. The magnitude of this inhibitory effect was found to be dependent on the dose of phenobarbitone. The significance of c-AMP-phosphodiesterase inhibition by phenobarbitone is discussed.
研究了苯巴比妥、茶碱、甲状腺素以及这些药物组合对大鼠肝脏微粒体苯胺羟化酶活性的早期影响，并将结果与苯巴比妥对体外纯化的环磷酸腺苷磷酸二酯酶的作用进行了比较。发现茶碱以及甲状腺素可模拟苯巴比妥对肝脏微粒体苯胺羟化酶活性的刺激作用。当使用苯巴比妥和甲状腺素时，其作用大致等于各自作用之和，但使用苯巴比妥和茶碱时未观察到相加作用。苯巴比妥在体外可抑制环磷酸腺苷磷酸二酯酶活性。发现这种抑制作用的强度取决于苯巴比妥的剂量。讨论了苯巴比妥抑制环磷酸腺苷磷酸二酯酶的意义。
