Feldman J D, Jacobs S C
Department of Surgery, University of Maryland School of Medicine, Baltimore.
J Urol. 1992 Aug;148(2 Pt 1):395-7. doi: 10.1016/s0022-5347(17)36609-0.
The Cincinnati Transplant Tumor Registry recorded 169 cases of renal carcinoma developing in transplant recipients. The great majority of these cases were of primary renal cell carcinoma developing in the recipient native kidneys. Renal carcinoma developing de novo in the renal allograft occurred 17 times, with a maximal interval to clinical development of 85 months after transplantation. The development of multicentric renal cell carcinoma in an allograft 156 months after transplantation is described. The 24-year-old white male recipient with Alport's syndrome received a cadaver renal allograft from a healthy 27-year-old black man who had died of a cerebral hemorrhage in 1977. At 13 years after transplantation the recipient had upper abdominal pain. Ultrasound revealed 2 incidental renal masses and a renal cyst in the allograft. Partial nephrectomy confirmed the presence of multicentric renal carcinoma. The graft was left in situ and immunosuppression was maintained. The recipient continued to do well with no evidence of disease 1 year postoperatively. Deoxyribonucleic acid banding demonstrated that the tumor and recipient blood were of different patterns.
辛辛那提移植肿瘤登记处记录了169例移植受者发生肾癌的病例。这些病例中的绝大多数是原发性肾细胞癌，发生于受者的自身肾脏。肾移植后新发生的肾癌有17例，临床发病的最长间隔时间为移植后85个月。本文描述了1例肾移植156个月后发生多中心肾细胞癌的病例。该24岁患有阿尔波特综合征的白人男性受者，接受了1977年死于脑出血的27岁健康黑人男性的尸体肾移植。移植13年后，受者出现上腹部疼痛。超声检查发现移植肾有2个偶然发现的肾肿物和1个肾囊肿。部分肾切除术证实存在多中心肾癌。移植肾原位保留，继续维持免疫抑制治疗。术后1年，受者情况良好，无疾病迹象。脱氧核糖核酸分型显示肿瘤与受者血液的分型不同。
