Noorlander I, Elte J W, Manintveld O C, Tournoy K G, Praet M M, van Meerbeeck J P, Aerts J G
Sint Franciscus Gasthuis, Department of Respiratory Diseases, Rotterdam, The Netherlands.
Lung Cancer. 2006 Feb;51(2):251-5. doi: 10.1016/j.lungcan.2005.08.015. Epub 2005 Dec 13.
Secretion of ectopic adrenocorticotropic hormone (ACTH) with consequently Cushing's syndrome is a rare paraneoplastic phenomenon. It has been described in a variety of malignancies, like bronchial carcinoids, small-cell lung carcinoma, thymoma, pancreatic carcinoma and other. In many cases of suspected ectopic ACTH secretion, it is difficult to histologically or cytochemically confirm the diagnosis. We present a 63-year-old woman with a recurrent poorly differentiated squamous cell lung carcinoma with clinical and biochemical features consistent with ectopic Cushing's syndrome. Immunocytochemical staining confirmed the secretion of ACTH by tumour cells.
分泌异位促肾上腺皮质激素（ACTH）并由此导致库欣综合征是一种罕见的副肿瘤现象。它已在多种恶性肿瘤中被描述，如支气管类癌、小细胞肺癌、胸腺瘤、胰腺癌等。在许多疑似异位ACTH分泌的病例中，很难通过组织学或细胞化学方法确诊。我们报告一名63岁女性，患有复发性低分化肺鳞状细胞癌，其临床和生化特征与异位库欣综合征相符。免疫细胞化学染色证实肿瘤细胞分泌ACTH。
