Giakkoupi P, Tambic-Andrasevic A, Vourli S, Skrlin J, Sestan-Crnek S, Tzouvelekis L S, Vatopoulos A C
Department of Microbiology, National School of Public Health, Athens, Greece.
Int J Antimicrob Agents. 2006 Jan;27(1):77-80. doi: 10.1016/j.ijantimicag.2005.09.013. Epub 2005 Dec 13.
Three Escherichia coli isolates resistant to third-generation cephalosporins but negative for extended-spectrum beta-lactamase production were isolated from hospitalised patients in Zagreb, Croatia, during June 2003 to February 2004. Resistance was due to the inducible production of a DHA-1 cephalosporinase. Each isolate contained an integron-associated bla(DHA-1)-ampR sequence carried by similar-sized plasmids, of which one was self-transferable. Serotyping and polymerase chain reaction typing using ERIC2 primer indicated that the isolates were distinct. This is the first description of DHA beta-lactamase production in E. coli.
2003年6月至2004年2月期间，在克罗地亚萨格勒布，从住院患者中分离出三株对第三代头孢菌素耐药但超广谱β-内酰胺酶检测呈阴性的大肠埃希菌。耐药性是由于诱导产生了DHA-1头孢菌素酶。每株分离菌都含有由大小相似的质粒携带的与整合子相关的bla(DHA-1)-ampR序列，其中一个质粒是可自我转移的。血清分型以及使用ERIC2引物的聚合酶链反应分型表明这些分离菌是不同的。这是关于大肠埃希菌中DHAβ-内酰胺酶产生的首次描述。
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