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Nucleic Acids Res. 2013 Jan 7;41(1):1-20. doi: 10.1093/nar/gks1039. Epub 2012 Nov 11.
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Regional outbreak of CTX-M-2 β-lactamase-producing Proteus mirabilis in Japan.日本产奇异变形杆菌中产 CTX-M-2 型β-内酰胺酶的区域性爆发。
J Med Microbiol. 2012 Dec;61(Pt 12):1727-1735. doi: 10.1099/jmm.0.049726-0. Epub 2012 Aug 30.
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The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes.铜绿假单胞菌 AmpC β-内酰胺酶调控因子 AmpR 的调控库包括毒力基因。
PLoS One. 2012;7(3):e34067. doi: 10.1371/journal.pone.0034067. Epub 2012 Mar 29.
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Characterization of a DHA-1-producing Klebsiella pneumoniae strain involved in an outbreak and role of the AmpR regulator in virulence.产 DHA-1 的肺炎克雷伯菌菌株的特征及其在爆发中的作用和 AmpR 调节剂在毒力中的作用。
Antimicrob Agents Chemother. 2012 Jan;56(1):288-94. doi: 10.1128/AAC.00164-11. Epub 2011 Oct 10.
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Crystal structure of the AmpR effector binding domain provides insight into the molecular regulation of inducible ampc beta-lactamase.AmpR 效应物结合结构域的晶体结构为诱导型 AmpC β-内酰胺酶的分子调控提供了新见解。
J Mol Biol. 2010 Jul 30;400(5):998-1010. doi: 10.1016/j.jmb.2010.05.040. Epub 2010 May 31.
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AmpC beta-lactamases.AmpC β-内酰胺酶
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Escherichia coli O157:H7 gene expression in the presence of catecholamine norepinephrine.大肠杆菌O157:H7在儿茶酚胺去甲肾上腺素存在下的基因表达。
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Resistance to gram-negative organisms due to high-level expression of plasmid-encoded ampC beta-lactamase blaCMY-4 promoted by insertion sequence ISEcp1.由于插入序列ISEcp1促进质粒编码的AmpCβ-内酰胺酶blaCMY-4高水平表达而导致对革兰氏阴性菌的耐药性。
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Transferable DHA-1 cephalosporinase in Escherichia coli.大肠杆菌中可转移的DHA-1头孢菌素酶
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AmpR在质粒编码的AmpCβ-内酰胺酶CFE-1高表达中的作用

Role of AmpR in the High Expression of the Plasmid-Encoded AmpC β-Lactamase CFE-1.

作者信息

Nakano Ryuichi, Nakano Akiyo, Yano Hisakazu, Okamoto Ryoichi

机构信息

Department of Microbiology and Infectious Diseases, Nara Medical University, Kashihara, Nara, Japan.

Department of Microbiology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

出版信息

mSphere. 2017 Aug 9;2(4). doi: 10.1128/mSphere.00192-17. eCollection 2017 Jul-Aug.

DOI:10.1128/mSphere.00192-17
PMID:28808689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5549177/
Abstract

CFE-1 is a unique plasmid-encoded AmpC β-lactamase with the regulator gene . It imparts high resistance to most cephalosporins with constitutive high-level β-lactamase activity. Here, the β-lactamase activities and expression levels of with or without were investigated. Results suggested that the resistance of CFE-1 to cephalosporins is caused by a substitution in AmpR, in which the Asp at position 135 is modified to Ala to allow the constitutive high-level expression (derepression) of .

摘要

CFE-1是一种具有调节基因的独特质粒编码AmpCβ-内酰胺酶。它对大多数头孢菌素具有高度耐药性，具有组成型高水平β-内酰胺酶活性。在此，研究了有无（此处原文缺失相关内容）时的β-内酰胺酶活性和表达水平。结果表明，CFE-1对头孢菌素的耐药性是由AmpR中的一个替代引起的，其中第135位的天冬氨酸被修饰为丙氨酸，以允许（此处原文缺失相关内容）的组成型高水平表达（去阻遏）。