Wilson R S, Tang Y, Aggarwal N T, Gilley D W, McCann J J, Bienias J L, Evans D A
Rush Alzheimer's Disease Center, Rush Institute for Healthy Aging, and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.
Neuroepidemiology. 2006;26(2):68-75. doi: 10.1159/000090251. Epub 2005 Dec 13.
The relation of psychotic symptoms to cognitive decline and mortality in Alzheimer's disease (AD) was examined during a mean of 2.2 years in 478 persons selected from clinical settings. Psychotic symptoms were ascertained at baseline and cognition was assessed semiannually with nine tests from which a global measure was formed. In analyses that controlled for age, sex, race, and education, hallucinations (29.6%), especially visual ones, were associated with more rapid global cognitive decline and increased mortality, even after controlling for baseline level of cognition and use of antipsychotic medication, and the association with mortality increased with higher level of education. Delusions and misperceptions were not strongly related to cognitive decline or mortality. The results suggest that hallucinations in Alzheimer's disease, particularly visual ones, are associated with more rapid progression.
在从临床环境中选取的478人中，对阿尔茨海默病（AD）患者的精神病性症状与认知衰退及死亡率之间的关系进行了为期平均2.2年的研究。在基线时确定精神病性症状，并每半年用九项测试评估认知情况，据此形成一项综合指标。在控制了年龄、性别、种族和教育程度的分析中，幻觉（29.6%），尤其是视幻觉，与更快速的整体认知衰退及死亡率增加相关，即使在控制了认知的基线水平和抗精神病药物使用情况之后依然如此，且与死亡率的关联随着教育程度的提高而增强。妄想和错觉与认知衰退或死亡率没有强烈关联。结果表明，阿尔茨海默病中的幻觉，尤其是视幻觉，与疾病进展更快有关。
