静脉注射氟康唑对兔内源性念珠菌性眼内炎抑制作用的研究。

Study of suppressive effect of intravenous fluconazole on endogenous Candida endophthalmitis in rabbits.

作者信息

Isobe Y, Hatano H

机构信息

Department of Ophthalmology, Yokohama City University School of Medicine, Japan.

出版信息

Jpn J Ophthalmol. 1992;36(1):23-7.

PMID:1635291

Abstract

The effect of intravenous fluconazole on endogenous Candida endophthalmitis in rabbits was investigated. Preventive and therapeutic experiments were carried out. In the preventive series, rabbits were injected intravenously with 5 mg/kg of fluconazole at 30 minutes, 1 day and 2 days after intravenous inoculation with Candida albicans spores. The control group received no medication. No treated rabbits developed ocular lesions and no Candida spores were isolated from the treated eyes. On the other hand, all control rabbits developed bilateral chorioretinitis and C. albicans was isolated invariably from the control eyes. In the therapeutic series, intravenous fluconazole (5 mg/kg body weight) was administered from 3 to 6 days after inoculation. All rabbits developed chorioretinitis and Candida spores were isolated from all eyes. Therefore, the results of this study prove that intravenous fluconazole is more effective in preventive use than in therapeutic use against endogenous Candida endophthalmitis in rabbits.

摘要

研究了静脉注射氟康唑对兔内源性念珠菌性眼内炎的影响。进行了预防和治疗实验。在预防组实验中，在白色念珠菌孢子静脉接种后30分钟、1天和2天，给兔子静脉注射5mg/kg氟康唑。对照组未用药。治疗组兔子未出现眼部病变，且治疗组眼睛未分离出念珠菌孢子。另一方面，所有对照兔均发生双侧脉络膜视网膜炎，且对照兔眼中均能分离出白色念珠菌。在治疗组实验中，接种后3至6天给予静脉注射氟康唑（5mg/kg体重）。所有兔子均发生脉络膜视网膜炎，且所有眼睛均分离出念珠菌孢子。因此，本研究结果证明，静脉注射氟康唑预防兔内源性念珠菌性眼内炎比治疗更有效。