Martsevich S Iu, Semenova Iu E, Alimova E V, Dmitrieva n A, Kozyreva M P, Koniakhina I P, Lukina Iu V, Egorov V A
Kardiologiia. 2005;45(11):42-5.
To assess efficacy and tolerability of a novel drug form of isosorbide-5-mononitrate in patients with ischemic heart disease and stable effort angina as compared with common isosorbide dinitrate pills.
Patients with stable class II-III effort angina (n=30) were included into a randomized crossover study in which they received isosorbide dinitrate (nitrosorbide, 10-20 mg t.i.d.) and long acting isosorbide-5-mononitrate (ephox-long, 50-100 mg o.d.) for 3 weeks each. Efficacy of treatment was assessed by clinical data and treadmill exercise tests. Questionnaires were used for registration of frequency and intensity of attacks of headache.
The use of both isosorbide dinitrate and 5-mononitrate was associated with significant improvements of exercise tolerance however effect of mononitrate lasted longer. Nitroglycerine requirement diminished during first week of use of both drugs and remained on this level by the end of 3-rd week of treatment with mononitrate but substantially rose by the end of treatment with dinitrate. Number of attacks of headache increased during first week of treatment with both drugs, became even higher by the end of use of dinitrate and decreased by the end of use of mononitrate.
Long acting form of isosorbide-5-mononitrate ephox-long taken once daily provides sufficient antianginal effect throughout a day and is better tolerated than nitrosorbide preparation of isosorbide dinitrate with moderately prolonged activity.
评估新型药物形式的5-单硝酸异山梨酯与普通硝酸异山梨酯片相比，在缺血性心脏病和稳定劳力性心绞痛患者中的疗效和耐受性。
将II-III级稳定劳力性心绞痛患者（n = 30）纳入随机交叉研究，患者分别接受硝酸异山梨酯（消心痛，10 - 20 mg，每日三次）和长效5-单硝酸异山梨酯（依姆多，50 - 100 mg，每日一次）治疗，各为期3周。通过临床数据和跑步机运动试验评估治疗效果。使用问卷记录头痛发作的频率和强度。
硝酸异山梨酯和5-单硝酸异山梨酯的使用均与运动耐量的显著改善相关，但单硝酸异山梨酯的效果持续时间更长。在两种药物使用的第一周，硝酸甘油需求量均减少，在单硝酸异山梨酯治疗的第3周结束时维持在该水平，但在硝酸异山梨酯治疗结束时大幅上升。在两种药物治疗的第一周，头痛发作次数均增加，在硝酸异山梨酯使用结束时更高，而在单硝酸异山梨酯使用结束时减少。
每日服用一次的长效5-单硝酸异山梨酯依姆多全天可提供足够的抗心绞痛效果，且耐受性优于硝酸异山梨酯的消心痛制剂，活性有适度延长。
