Kazakov A V, Muller P, Beltrami A P, Pfeiffer P, Chizelli D, Bem M
Kardiologiia. 2005;45(11):65-75.
A concept of impossibility of appearance of novel cardiomyocytes in the heart of adult men in exchange for those lost due to cardiovascular diseases had dominated medicine and biology for many long decades. However ability of human myocardium to regenerate was demonstrated during recent years in multiple studies. This dictated necessity to reconsider previously generally accepted concept. At present researchers and practicing physicians actively discuss possibility of the use of transplantation of bone marrow stem cells, proper cardiac stem cells, skeletal muscle myoblasts or precursors of endothelial cells in patients with myocardial infarction and heart failure in order to restore normal cardiac structure and function. Another potential method of restoration of the myocardium in patients with cardiovascular diseases is the use of cytokines which stimulate migration of stem cells into myocardium and their differentiation into cardiomyocytes.
几十年来，一种观念在医学和生物学领域占据主导地位，即成年男性心脏中不可能出现新的心肌细胞来替代因心血管疾病而损失的细胞。然而，近年来多项研究证实了人类心肌具有再生能力。这使得重新审视此前普遍接受的观念成为必要。目前，研究人员和执业医师正在积极讨论，对于心肌梗死和心力衰竭患者，使用骨髓干细胞、心脏固有干细胞、骨骼肌成肌细胞或内皮细胞前体进行移植，以恢复心脏正常结构和功能的可能性。心血管疾病患者心肌恢复的另一种潜在方法是使用细胞因子，刺激干细胞向心肌迁移并分化为心肌细胞。
