Spindler Matthias, Schmidt Michael, Geier Oliver, Sandstede Jörn, Hahn Dietbert, Ertl Georg, Beer Meinrad
Department Internal Medicine I/Center of Cardiovascular Medicine, University Würzburg, Würzburg, Germany.
J Cardiovasc Magn Reson. 2005;7(5):853-4. doi: 10.1080/10976640500295540.
An impaired high-energy phosphate metabolism might play a critical role in the pathogenesis of right ventricular (RV) failure due to chronic pulmonary arterial hypertension (PAH). 31P-NMR spectroscopy is well established for measurements of high-energy phosphate metabolites in various left ventricular heart diseases, however, mainly for technical and sensitivity reasons, its successful transfer for measurements in the RV is currently missing. In the present study, the usefulness of this non-invasive approach is not only shown in RV failure due to PAH but also tested during subsequent therapy.
高能磷酸代谢受损可能在慢性肺动脉高压（PAH）所致右心室（RV）衰竭的发病机制中起关键作用。31P-NMR光谱法在各种左心室疾病中测量高能磷酸代谢物方面已得到广泛应用，然而，主要由于技术和灵敏度原因，目前尚缺乏将其成功应用于右心室测量的方法。在本研究中，这种非侵入性方法不仅在PAH所致右心室衰竭中显示出有用性，而且在后续治疗过程中也进行了测试。
