Hakala Roy V
Minnesota Craniofacial Center Midway, 1690 University Avenue West, Suite 390, Saint Paul, MN 55104, USA.
Cranio. 2005 Oct;23(4):283-8. doi: 10.1179/crn.2005.040.
Proliferation therapy, or "prolotherapy," is also known as regenerative injection therapy (RIT). Since the 1930s, the technique has been used to stabilize injured joints and to relieve joint pain. This article reviews the history and scientific literature regarding prolotherapy and describes the application of the technique to treat injured or unstable temporomandibular joints (TMJ). Alternative medicaments and the likely mechanisms of action are discussed. A brief preliminary summary of a retrospective clinical study of the efficacy of prolotherapy is included. The study shows that prolotherapy can be an effective therapeutic modality that reduces TMJ pain and joint noise in a majority of patients who have reached a plateau with use of an intraoral appliance, physical therapy, and home care.
增殖疗法，或称“注射增殖疗法”，也被称为再生注射疗法（RIT）。自20世纪30年代以来，该技术一直用于稳定受伤关节并缓解关节疼痛。本文回顾了关于注射增殖疗法的历史和科学文献，并描述了该技术在治疗受伤或不稳定的颞下颌关节（TMJ）中的应用。还讨论了替代药物及其可能的作用机制。文中包含了一项关于注射增殖疗法疗效的回顾性临床研究的简要初步总结。该研究表明，对于大多数使用口内矫治器、物理治疗和家庭护理后病情已达到稳定状态的患者而言，注射增殖疗法可能是一种有效的治疗方式，可减轻颞下颌关节疼痛和关节杂音。
