Glebov A N, Zinchuk V V
Ross Fiziol Zh Im I M Sechenova. 2005 Sep;91(9):1052-9.
Lipopolysacharide from Escherichia coli was intravenously administered to rats (5.0 mg/kg). L-arginine-No system was modified by intravenous injection of L-arginine, N(G)-nitro-L-arginine methyl ester or L-lysine-N(G)-acetamidine (nitric oxide synthase (NOS) substrate, nonselective NOS inhibitor, and selective inducible NOS inhibitor, respectively.) Lipopolysacharide-induced disorders of blood oxygen transport were the least during the selective inducible NOS inhibition. The protective effects of L-arginine and N(G)-nitro-L-arginine methyl ester were less prominent. Such features of NOS modification effect on the blood oxygen transport suggest that activation of inducible NOS may change the hemoglobin-oxygen affinity during the lipopolysacharide treatment.
将来自大肠杆菌的脂多糖静脉注射给大鼠（5.0毫克/千克）。通过静脉注射L-精氨酸、N（G）-硝基-L-精氨酸甲酯或L-赖氨酸-N（G）-乙脒（分别为一氧化氮合酶（NOS）底物、非选择性NOS抑制剂和选择性诱导型NOS抑制剂）来改变L-精氨酸-NO系统。在选择性诱导型NOS抑制期间，脂多糖诱导的血液氧运输紊乱最少。L-精氨酸和N（G）-硝基-L-精氨酸甲酯的保护作用不太明显。NOS修饰对血液氧运输的这种作用特征表明，在脂多糖治疗期间，诱导型NOS的激活可能会改变血红蛋白与氧的亲和力。
