将源自炔丙基恶唑烷二酮的手性铜试剂添加到醛类中。
Addition of a chiral copper reagent derived from propargylic oxazolidininone to aldehydes.
作者信息
Alouane Nacira, Bernaud Frederic, Marrot Jerôme, Vrancken Emmanuel, Mangeney Pierre
机构信息
Laboratoire de Chimie Organique, UMR 761, Institut de Chimie Moléculaire FR 2769, Université Pierre et Marie Curie, 75252 Paris Cedex 05, France.
出版信息
Org Lett. 2005 Dec 22;7(26):5797-800. doi: 10.1021/ol0522743.
PMID:16354069
Abstract
[reaction: see text] The copper reagent arising from an optically pure propargylic oxazolidinone was found to react regio- and diastereoselectively with aldehydes, leading, in a one-pot procedure, to the anti homopropargylic amino alcohols derivatives in good yields.
摘要
[反应：见正文] 发现由光学纯的炔丙基恶唑烷酮产生的铜试剂与醛发生区域和非对映选择性反应，通过一锅法以良好的产率得到反式高炔丙基氨基醇衍生物。
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