基于胆酸的水溶液中二元羧酸盐和酸性氨基酸荧光传感器。

Cholic-acid-based fluorescent sensor for dicarboxylates and acidic amino acids in aqueous solutions.

作者信息

Liu Shun-Ying, Fang Lei, He Yong-Bing, Chan Wing-Hong, Yeung Kai-Tai, Cheng Yuen-Kit, Yang Rong-Hua

机构信息

Department of Chemistry, Wuhan University, Hubei, China.

出版信息

Org Lett. 2005 Dec 22;7(26):5825-8. doi: 10.1021/ol052341t.

DOI:10.1021/ol052341t

PMID:16354076

Abstract

[structure: see text] The binding affinities of a cholic-acid-based fluorescent neutral receptor toward dicarboxylate anions and amino acids have been investigated in a CH3OH/H2O system (1:1, 0.01 M HEPES buffer, pH = 7.4) by fluorescence titration experiments. The synthetic host bearing four convergent functionalities strongly binds glutamate via multiple hydrogen bonds with a binding constant of (5.57 +/- 0.88) x 10(6).

摘要

[结构：见正文] 通过荧光滴定实验，在CH3OH/H2O体系（1:1，0.01 M HEPES缓冲液，pH = 7.4）中研究了一种基于胆酸的荧光中性受体对二羧酸根阴离子和氨基酸的结合亲和力。带有四种收敛功能的合成主体通过多个氢键与谷氨酸强烈结合，结合常数为(5.57±0.88)×10(6)。