Saksena Nitin K, Wang Bin, Steain Megan, Yang Rong Ge, Zhang Lin Qi
Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead NSW 2145 Sydney, Australia.
Cell Res. 2005 Nov-Dec;15(11-12):953-61. doi: 10.1038/sj.cr.7290373.
Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV-1 subtypes, consequent emergence of recombinant and novel forms of HIV-1 in China, and the implications this may have on HIV diversity and the development of effective vaccines. In addition it also examines the dissemination of primary drug resistance in therapy naïve patients, as well as co-infections with two other important viruses-hepatitis B and C. The main purpose of this review is to provide a current snapshot of HIV-1 pathogenesis in China and possibly shed some light on the future of HIV evolution, and potential challenges for future vaccine and anti-retroviral therapeutics against HIV strains in this area.
已有多项综述聚焦于中国不同地理区域的HIV感染性质及其传播情况。相比之下，本综述全面更新了中国多种HIV-1亚型的流行情况、由此出现的HIV-1重组体和新形式，以及这可能对HIV多样性和有效疫苗研发产生的影响。此外，还研究了初治患者中原发性耐药的传播情况，以及与另外两种重要病毒——乙型和丙型肝炎病毒的合并感染情况。本综述的主要目的是呈现中国HIV-1发病机制的现状，可能为HIV进化的未来、以及该地区针对HIV毒株的未来疫苗和抗逆转录病毒治疗所面临的潜在挑战提供一些启示。
