Platts-Mills Thomas A E, Erwin Elizabeth A, Woodfolk Judith A, Heymann Peter W
Asthma and Allergic Disease Center, University of Virginia, Charlottesville, VA 22908, USA.
Chem Immunol Allergy. 2006;91:3-15. doi: 10.1159/000090225.
Despite the strong and consistent association between immediate hypersensitivity, allergy, asthma and exposure, there is still controversy about the role inhaled allergen plays and about the timing of events related to sensitization. However, IgE antibodies are essential for the asthmatic response and the symptoms are much more closely associated with IgE antibodies to perennial than to seasonal allergens. Although there have been many changes in our environment, none of these alone explains the consistency or the scale of the rise in asthma over the 40 years between 1960 and 2000.
尽管速发型超敏反应、过敏、哮喘与暴露之间存在强烈且一致的关联，但关于吸入性变应原所起的作用以及与致敏相关事件的时间安排仍存在争议。然而，IgE抗体对于哮喘反应至关重要，并且症状与针对常年性变应原而非季节性变应原的IgE抗体关联更为密切。尽管我们的环境发生了许多变化，但这些变化单独都无法解释1960年至2000年这40年间哮喘发病率上升的持续性或规模。
